PATHOPHYSIOLOGICAL MECHANISMS OF HEART FAILURE DEVELOPMENT IN PATIENTS WITH DIABETES MELLITUS

Authors

  • Noilaxon Saidolimxon qizi Azizova Author

Keywords:

myocardial insulin resistance, advanced glycation end-products, mitochondrial dysfunction, oxidative stress, cardiac remodeling, diastolic dysfunction, lipotoxicity, renin-angiotensin-aldosterone system, endothelial dysfunction

Abstract

this thesis examines the multifactorial pathophysiological mechanisms underlying heart failure development in diabetic patients, integrating metabolic, structural, and molecular perspectives. The investigation elucidates how chronic hyperglycemia, insulin resistance, and metabolic derangements converge to precipitate myocardial dysfunction through oxidative stress, mitochondrial dysfunction, advanced glycation end-product accumulation, and neurohormonal dysregulation. These findings illuminate critical therapeutic targets and underscore the imperative for integrated cardiovascular-metabolic risk management strategies.

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Published

2025-10-30

Issue

Vol. 3 No. 10 (2025): ZAMONAVIY TIBBIYOT VA TABIIY FANLARDA ILMIY-INNAVATSION TADQIQOTLAR

Section

Articles